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KMID : 0882420090760000015
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Korean Journal of Medicine
2009 Volume.76 No. 0 p.15 ~ p.21
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Three cases of extensive liver metastasis in neuroendocrine tumors
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Park Eui-Ju
Jeon Seong-Ran
Kim Dae-Yong
Jang Jae-Young
Kim Jung-Hoon
Jin So-Young
Shim Chan-Sup
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Abstract
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Malignant neuroendocrine tumors have the histological features of malignant tumors, and localized invasion and distant metastasis can occur. After clinical presentation, patients with neuroendocrine tumors usually show rapid deterioration. The first case involved a patient who underwent treatment for poorly differentiated adenocarcinoma of the lung. A percutaneous liver biopsy was performed to look for diffuse infiltration of the tumor in the liver. As a result, the patient was diagnosed with large-cell neuroendocrine carcinoma of the lung with diffuse liver metastasis. The other two patients presented with liver masses. Liver biopsies revealed metastatic neuroendocrine tumors of the liver. In patients presenting with diffuse hepatic infiltration of a tumor, a neuroendocrine tumor should be considered in the diagnosis, and immunohistochemical staining and further studies should be performed to locate the origin of the tumor. We report three cases of neuroendocrine tumors with diffuse liver metastasis.
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KEYWORD
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Neuroendocrine tumor, Liver, Neoplasm metastasis
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